How Probiotics Improve Colic: A Rundown of Recent Research

As a parent of a baby with colic, you want nothing more than to be able to soothe your crying infant. There is hope. Research has shown that giving infants with colic probiotics can significantly lower the number of minutes they cry every day. How Probiotics Improve Colic can be seen in a number of ways.

Meta-analyses and systematic reviews, in which researchers examine data from several studies, have found that probiotics  reduce the amount of time newborns with colic spend crying and seem in distress. In one 2020 meta-analysis that included 1,319 newborns, babies who were given probiotics were more than two times more likely to experience a 50% reduction in crying compared to newborns who were given a placebo, that didn’t include probiotics.

And in a systematic review published in 2020, the amount of time breastfed babies with colic who were given probiotics spent crying fell by 33 to 76 minutes a day. 

How probiotics improve colic, is based on research that shows the benefits of probiotics.  The American Academy of Family Physicians has recommended the supplements for breastfed babies with colic.

How probiotics  improve colic

Doctors think colic could be a result of problems with a baby’s gastrointestinal tract. Doctors have theorized that colic happens, in part, when a baby’s gut has a less diverse number of bacteria, which can lead to gas, constipation, and pain.
Research has found that babies with colic have lower amounts of two types of beneficial bacteria. These bacteria are called Lactobacilli and Bifidobacterium.  Alternatively, they have found that these babies have higher amounts of other types of bacteria that can cause gas and pain.
Probiotics replace the good bacteria in the gut, leading to a healthier GI tract and a healthier and happier baby.

Which probiotic supplement is best for my baby?

Probiotics are clearly worth a try if your baby has colic. The next step is choosing the right supplement. A number of different strains have been included in  studies, and several are on the market.
The best probiotic supplement, however, should include research-tested strains of probiotics that specifically focus on relieving colic in newborns, rather than digestive or immune health in general.

Colic Relief Plus®

Colic Relief Plus® by Second to Mom uses two strains found naturally in humans in the Amazon Rainforest that have been tested in medical studies to benefit babies with colic.

The Strains

Those strains are P.pentosaceus KABPTM-041 and B.longum KABPTM-042.

The Research

90 babies with colic were given probiotic strains in a randomized, double-blind, placebo-controlled trial. Results are soon to be published. In the study, half of the babies were given the strains in Colic Relief Plus® while the other half received a placebo. In the babies who received the probiotics, the amount of time they cried every day fell by more than 60% in just seven days. The probiotic drops continued to soothe the babies for 21 days. It’s important to note, however, that some babies needed two or three weeks of the daily probiotic drops to show improvement. The probiotics also improved the diversity of the bacteria in the gut of the babies, which supports a healthy GI tract and leads to less colic.

Bottle OR Breast-Fed

The probiotic strains included in Colic Relief Plus® were shown to be effective in babies who were breastfed, bottle fed, and given both breastmilk and formula. Other probiotics on the market include strains that have primarily been tested on breastfed babies. This is important, because colic is more common among babies who are formula-fed.

Colic Relief Plus® probiotic drops include the exact formulation and dosage of the two beneficial strains of bacteria used in the study. It featured one billion colony forming units in five drops added to milk or formula daily. The supplement also comes with a dropper that can be sanitized after each use to prevent mold.

One in five babies are affected by colic, but relief is out there. Giving your baby probiotic drops might be the key to bringing  happier days.

To learn more about  how infant probiotic drops are used to treat fussy newborns, browse through our Education Center  — we’re here to help

The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials – PubMed (
Comparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines – PubMed (
Infantile Colic: Recognition and Treatment – American Family Physician (
Colic Treatment – Medical Trial – Second to Mom
Chen K, et al. A Randomized, Double-blind, Placebo-controlled Trial with Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330 to Treat Infant Colic (Currently not available to the public without an NDA)


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colic relief plus

Colic Relief Plus™

Combat your baby’s colic with Second to Mom’s Colic Relief Plus™ supplement.

These drops worked great for my little one’s colic! Every once in a while he would get colicky from gas pain and we would just have to ride out the wave because nothing worked. I could give him these drops right along with his vitamin D drops just fine. We haven’t had a colic spell since using the drops. Great product!


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